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Recombinant CDKN2A Protein

Original price was: $150.00.Current price is: $37.50.

SKU: PW14836849427 Category:

Description

Recombinant CDKN2A Protein

Catalog number: B2017559
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 g
Molecular Weight or Concentration: 17.36 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80C
Keywords: Cyclin-dependent kinase inhibitor 2A, CDK4I, MTS-1, p16-INK4, p16INK4A
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um.

References

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  • Luo C, Zhou S, Zhou Z, Liu Y, Yang L, Liu J, Zhang Y, Li H, Liu Y, Hou FF, Zhou L. Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells J Am Soc Nephrol. 2018 Apr;29(4):1238-1256.
  • Rodier F, Copp JP, Patil CK, Hoeijmakers WA, Muoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion Nat Cell Biol. 2009 Aug;11(8):973-9.
  • Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T. A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition Sci Rep. 2014 Feb 6;4:4012.
  • Abaandou L, Sharma AK, Shiloach J. Knockout of the caspase 8-associated protein 2 gene improves recombinant protein expression in HEK293 cells through up-regulation of the cyclin-dependent kinase inhibitor 2A gene Biotechnol Bioeng. 2021 Jan;118(1):186-198.
  • Seavey CN, Hallett A, Li S, Che K, Pobbati AV, Ma S, Burtscher A, Kanai R, Lamar JM, Rubin BP. Loss of CDKN2A Cooperates with WWTR1(TAZ)-CAMTA1 Gene Fusion to Promote Tumor Progression in Epithelioid Hemangioendothelioma Clin Cancer Res. 2023 Jul 5;29(13):2480-2493.
  • Chen YH, Zhang X, Ko KY, Hsueh MF, Kraus VB. CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts Oxid Med Cell Longev. 2022 Feb 23;2022:5503575.
  • Liu Y, Sharpless NE. Tumor suppressor mechanisms in immune aging Curr Opin Immunol. 2009 Aug;21(4):431-9.
  • Zhao Q, Dong D, Chu H, Man L, Huang X, Yin L, Zhao D, Mu L, Gao C, Che J, Liu Q. lncRNA CDKN2A-AS1 facilitates tumorigenesis and progression of epithelial ovarian cancer via modulating the SOSTDC1-mediated BMP-SMAD signaling pathway Cell Cycle. 2021 Jun;20(12):1147-1162.