Description
Human ASNA1 Protein
| Catalog number: | B2011794 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 100 g |
| Molecular Weight or Concentration: | 41.2 kDa |
| Supplied as: | Solution |
| Applications: | molecular tool for various biochemical applications |
| Storage: | -20 C |
| Keywords: | GET3 protein, ASNA-1 protein, ASNA-1, ASNA1, ARSA1 protein, ASNA 1 protein, ASNA 1, hASNA-I protein, ARSA-I protein, TRC40 protein, ATPase ASNA1 protein, ASNA-I protein |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Hemmingsson O, Njd M, Kao G, Naredi P. Increased sensitivity to platinating agents and arsenite in human ovarian cancer by downregulation of ASNA1 Oncol Rep. 2009 Oct;22(4):869-75.
- Vilardi F, Lorenz H, Dobberstein B. WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane J Cell Sci. 2011 Apr 15;124(Pt 8):1301-7.
- Favaloro V, Vilardi F, Schlecht R, Mayer MP, Dobberstein B. Asna1/TRC40-mediated membrane insertion of tail-anchored proteins J Cell Sci. 2010 May 1;123(Pt 9):1522-30.
- Verhagen JMA, van den Born M, van der Linde HC, G J Nikkels P, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, Verheijen FW, Hassel D, Hofstra RMW, Hegde RS, van Hasselt PM, van Ham TJ, van de Laar IMBH. Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy Circ Genom Precis Med. 2019 Sep;12(9):397-406.
- Hradsky J, Raghuram V, Reddy PP, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y, Kreutz MR, Mikhaylova M. Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone J Biol Chem. 2011 Oct 21;286(42):36762-76.
- Ott M, Marques D, Funk C, Bailer SM. Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions Virol J. 2016 Oct 20;13(1):175.
- Hemmingsson O, Zhang Y, Still M, Naredi P. ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite Cancer Chemother Pharmacol. 2009 Feb;63(3):491-9.
- Chen J, Cheng J, Yi J, Xie B, Lin L, Liu Z, Zhao H, Wang B, Ai Z, Yang Y, Wei H. Differential expression and response to arsenic stress of MRPs and ASAN1 determine sensitivity of classical multidrug-resistant leukemia cells to arsenic trioxide Leuk Res. 2016 Nov;50:116-122.
- Horst D, Favaloro V, Vilardi F, van Leeuwen HC, Garstka MA, Hislop AD, Rabu C, Kremmer E, Rickinson AB, High S, Dobberstein B, Ressing ME, Wiertz EJ. EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP J Immunol. 2011 Mar 15;186(6):3594-605.
