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[Pyr3]-Amyloid -Protein (Human, 3-42)

[Pyr3]-Amyloid -Protein (Human, 3-42)

Original price was: $149.00.Current price is: $37.25.

SKU: PW14836853801 Category:

Description

[Pyr3]-Amyloid -Protein (Human, 3-42)

Catalog number: MDP0736
CAS Number: 120721-97-3
Sequence: Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Amount: 500 ug
Molecular Weight: 4309.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References

  • Chang HH, Cheng YC, Tsai WC, Tsao MJ, Chen Y. Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells Cell Physiol Biochem. 2018;48(4):1694-1702.
  • Lu M, Fang XX, Shi DD, Liu R, Ding Y, Zhang QF, Wang HQ, Tang JM, He XJ. A Selective TRPC3 Inhibitor Pyr3 Attenuates Myocardial Ischemia/Reperfusion Injury in Mice Curr Med Sci. 2020 Dec;40(6):1107-1113.
  • Abdoul-Azize S, Buquet C, Vannier JP, Dubus I. Pyr3, a TRPC3 channel blocker, potentiates dexamethasone sensitivity and apoptosis in acute lymphoblastic leukemia cells by disturbing Ca(2+) signaling, mitochondrial membrane potential changes and reactive oxygen species production Eur J Pharmacol. 2016 Aug 5;784:90-8.
  • Banks GR, Taylor SY. Cloning of the PYR3 gene of Ustilago maydis and its use in DNA transformation Mol Cell Biol. 1988 Dec;8(12):5417-24.
  • Koenig S, Schernthaner M, Maechler H, Kappe CO, Glasnov TN, Hoefler G, Braune M, Wittchow E, Groschner K. A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling J Pharmacol Exp Ther. 2013 Jan;344(1):33-40.
  • Munakata M, Shirakawa H, Nagayasu K, Miyanohara J, Miyake T, Nakagawa T, Katsuki H, Kaneko S. Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice Stroke. 2013 Jul;44(7):1981-7.
  • Abdoul-Azize S, Dubus I, Vannier JP. [Modulation of glucocorticoid sensitivity in acute lymphoblastic leukemia: Pyr3, a new therapeutic tool?] Med Sci (Paris). 2017 Feb;33(2):130-132.
  • Spanos A, Kanuga N, Holden DW, Banks GR. The Ustilago maydis pyr3 gene: sequence and transcriptional analysis Gene. 1992 Aug 1;117(1):73-9.
  • Kiyonaka S, Kato K, Nishida M, Mori Y. [Pharmacological properties of novel TRPC channel inhibitors] Yakugaku Zasshi. 2010 Mar;130(3):303-11.

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