Description
Human Lanosterol 14–demethylase
| Catalog number: | B2016776 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 50 g |
| Molecular Weight or Concentration: | 52.71 kDa |
| Supplied as: | Solution |
| Applications: | a molecular tool for various biochemical applications |
| Storage: | -80C |
| Keywords: | Lanosterol 14–demethylase (human, recombinant) |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Trsken ER, Adamska M, Arand M, Zarn JA, Patten C, Vlkel W, Lutz WK. Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles Toxicology. 2006 Nov 10;228(1):24-32.
- Rozman D, Strmstedt M, Waterman MR. The three human cytochrome P450 lanosterol 14 alpha-demethylase (CYP51) genes reside on chromosomes 3, 7, and 13: structure of the two retrotransposed pseudogenes, association with a line-1 element, and evolution of the human CYP51 family Arch Biochem Biophys. 1996 Sep 15;333(2):466-74.
- Lamb DC, Kelly DE, Waterman MR, Stromstedt M, Rozman D, Kelly SL. Characteristics of the heterologously expressed human lanosterol 14alpha-demethylase (other names: P45014DM, CYP51, P45051) and inhibition of the purified human and Candida albicans CYP51 with azole antifungal agents Yeast. 1999 Jun 30;15(9):755-63.
- van den Brink HJ, van Nistelrooy HJ, de Waard MA, van den Hondel CA, van Gorcom RF. Increased resistance to 14 alpha-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14 alpha-demethylase (cyp51) and the A. niger cytochrome P450 reductase (cprA) genes J Biotechnol. 1996 Aug 20;49(1-3):13-8.
- Nitahara Y, Aoyama Y, Horiuchi T, Noshiro M, Yoshida Y. Purification and characterization of rat sterol 14-demethylase P450 (CYP51) expressed in Escherichia coli J Biochem. 1999 Nov;126(5):927-33.
- Masamrekh R, Kuzikov A, Veselovsky A, Toropygin I, Shkel T, Strushkevich N, Gilep A, Usanov S, Archakov A, Shumyantseva V. Interaction of 17-hydroxylase, 17(20)-lyase (CYP17A1) inhibitors abiraterone and galeterone with human sterol 14-demethylase (CYP51A1) J Inorg Biochem. 2018 Sep;186:24-33.
- Lamb DC, Kaderbhai NN, Venkateswarlu K, Kelly DE, Kelly SL, Kaderbhai MA. Human sterol 14alpha-demethylase activity is enhanced by the membrane-bound state of cytochrome b(5) Arch Biochem Biophys. 2001 Nov 1;395(1):78-84.
- Trsken ER, Straube E, Lutz WK, Vlkel W, Patten C. Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS J Am Soc Mass Spectrom. 2004 Aug;15(8):1216-21.
- Jackson CJ, Lamb DC, Marczylo TH, Parker JE, Manning NL, Kelly DE, Kelly SL. Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis Biochem Biophys Res Commun. 2003 Feb 7;301(2):558-63.
