Description
(2-hydroxypropyl)-alpha-cyclodextrin Solution 10% (w/v)
| Catalog | K1010005B |
| Lot | Batch Dependent |
| Expiration | Batch Dependent |
| Amount | 25 mL |
| Concentration | 10% (w/v) |
| Supplied as | Solution |
| Applications | Solubility enhancement, molecular assemblies, organic synthesis |
| Storage | 28C |
| Keywords | HPCD, HPCD, 2hydroxypropylCD, HP–CD, 2OHpCD |
| Grade | Biotechnology grade; ultrapure water, 0.22 m filtered |
This 10% (w/v) solution of (2-hydroxypropyl)-alpha-cyclodextrin (HPCD) is a versatile reagent used in solubility enhancement, hostguest chemistry, and formulation development. HPCD is a modified cyclic oligosaccharide that improves the aqueous solubility of poorly soluble compounds by forming inclusion complexes. Its alpha-cyclodextrin backbone offers a smaller cavity size, making it ideal for encapsulating low-molecular-weight hydrophobic guests.
Supplied as a clear, ready-to-use solution in ultrapure water, this reagent is filtered through 0.22 m membranes and packaged in 25 mL aliquots. It is widely used in pharmaceutical formulation, supramolecular chemistry, and analytical method development. Researchers working in drug delivery, molecular encapsulation, and solubilization of bioactive compounds will find this reagent highly effective and reproducible.
Key benefits:
- 10% (w/v) HPCD solution for solubility enhancement
- Supports hostguest chemistry and molecular encapsulation
- Filtered through 0.22 m for analytical compatibility
- Ideal for pharmaceutical, biochemical, and synthetic workflows
- Supplied in ultrapure water; biotechnology grade
Indication for Use:
This product is for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.
References:
1: Hoque S, Kondo Y, Sakata N, Yamada Y, Fukaura M, Higashi T, Motoyama K, Arima
H, Higaki K, Hayashi A, Komiya T, Ishitsuka Y, Irie T. Differential Effects of
2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells.
Int J Mol Sci. 2020 Jan 30;21(3):898.
2: Tomono K, Goto H, Suzuki T, Ueda H, Nagai T, Watanabe J. Interaction of
iodine with 2-hydroxypropyl-alpha-cyclodextrin and its bactericidal activity.
Drug Dev Ind Pharm. 2002 Nov;28(10):1303-9.
3: Motoyama K, Hashimoto Y, Hirayama F, Uekama K, Arima H. Inhibitory effects of
2,6-di-O-methyl-alpha-cyclodextrin on poly I:C signaling in macrophages. Eur J
Pharm Sci. 2009 Feb 15;36(2-3):285-91.
4: Holm R, Schnbeck C, Askjr S, Jensen H, Westh P, stergaard J. Complexation
of tauro- and glyco-conjugated bile salts with -cyclodextrin and hydroxypropyl-
-cyclodextrin studied by affinity capillary electrophoresis and molecular
modelling. J Sep Sci. 2011 Nov;34(22):3221-30.
5: Zarzycki PK, Ohta H, Saito Y, Jinno K. Interaction of native alpha-
cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl
derivatives with selected organic low molecular mass compounds at elevated and
subambient temperature under RP-HPLC conditions. Anal Bioanal Chem. 2008
Aug;391(8):2793-801.
6: Liu B, Li W, Nguyen TA, Zhao J. Empirical, thermodynamic and quantum-chemical
investigations of inclusion complexation between flavanones and
(2-hydroxypropyl)-cyclodextrins. Food Chem. 2012 Sep 15;134(2):926-32.
7: Terekhova IV, Scriba GK. Study on complex formation of biologically active
pyridine derivatives with cyclodextrins by capillary electrophoresis. J Pharm
Biomed Anal. 2007 Nov 30;45(4):688-93.
8: Rizzi V, Matera S, Semeraro P, Fini P, Cosma P. Interactions between
4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular
structures in aqueous solutions. Beilstein J Org Chem. 2016 Mar 21;12:549-63.
9: Warne LN, Beths T, Whittem T, Carter JE, Bauquier SH. A review of the
pharmacology and clinical application of alfaxalone in cats. Vet J. 2015
Feb;203(2):141-8.
10: Kimura K, Hirayama F, Arima H, Uekama K. Solid-state 13C nuclear magnetic
resonance spectroscopic study on amorphous solid complexes of tolbutamide with
2-hydroxypropyl-alpha- and -beta-cyclodextrins. Pharm Res. 1999
Nov;16(11):1729-34.
