Description
Human ALK4 Protein Active
| Catalog number: | B2013999 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 10 g |
| Molecular Weight or Concentration: | 63.8 kDa |
| Supplied as: | N/A |
| Applications: | molecular tool for various biochemical applications |
| Storage: | 20C |
| Keywords: | ALK4 Protein |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Fujiki K, Inamura H, Sugaya T, Matsuoka M. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms Cell Death Differ. 2019 Nov;26(11):2371-2385.
- Krapacher FA, Fernndez-Surez D, Andersson A, Carrier-Ruiz A, Ibez CF. Convergent dopamine and ALK4 signaling to PCBP1 controls FosB alternative splicing and cocaine behavioral sensitization EMBO J. 2022 Aug 1;41(15):e110721.
- Inman GJ, Nicols FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7 Mol Pharmacol. 2002 Jul;62(1):65-74.
- Chen M, Sun Y, Wang Q, Li Y. Reduction of Activin Receptor-Like Kinase 4 Expression Ameliorates Myocardial Ischemia/Reperfusion Injury through Inhibiting TGF_ Signaling Pathway Anal Cell Pathol (Amst). 2022 Mar 31;2022:5242323.
- Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W. Identification of a functional binding site for activin on the type I receptor ALK4 J Biol Chem. 2003 Jun 6;278(23):21129-35.
- Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF. ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus Dev Biol. 2004 Apr 15;268(2):280-94.
- Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, M_ller S, Knapp S. A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5 ACS Chem Biol. 2020 Apr 17;15(4):862-870.
- Wang N, Lu L, Cao QF, Qian S, Ding J, Wang C, Duan H, Shen H, Qi J. Partial inhibition of activin receptor-like kinase 4 alleviates bladder fibrosis caused by bladder outlet obstruction Exp Cell Res. 2021 Sep 1;406(1):112724.
- Li Y, Zhong W, Zhu M, Li M, Yang Z. miR-185 inhibits prostate cancer angiogenesis induced by the nodal/ALK4 pathway BMC Urol. 2020 May 4;20(1):49.
