Description
Human CNOT8 Protein
| Catalog number: | B2011994 |
| Lot number: | Batch Dependent |
| Expiration Date: | Batch dependent |
| Amount: | 100 g |
| Molecular Weight or Concentration: | 250 g/mL |
| Supplied as: | Solution |
| Applications: | molecular tool for various biochemical applications |
| Storage: | -20 C |
| Keywords: | CCR4-NOT transcription complex subunit 8 protein, CAF1 protein, CALIF protein, hCAF1 protein, POP2 protein, CNOT8, CNOT 8, CNOT-8, CNOT8 protein, CNOT 8 protein, CNOT-8 protein |
| Grade: | Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity>18 M-cm) and are filtered through 0.22 um. |
References
- Du H, Zhao Y, He J, Zhang Y, Xi H, Liu M, Ma J, Wu L. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex Nat Commun. 2016 Aug 25;7:12626.
- Doidge R, Mittal S, Aslam A, Winkler GS. Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex Biochem Soc Trans. 2012 Aug;40(4):896-901.
- Winkler GS. The mammalian anti-proliferative BTG/Tob protein family J Cell Physiol. 2010 Jan;222(1):66-72.
- Collart MA, Panasenko OO. The Ccr4-Not Complex: Architecture and Structural Insights Subcell Biochem. 2017;83:349-379.
- Almasmoum HA, Airhihen B, Seedhouse C, Winkler GS. Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma Leuk Lymphoma. 2021 Feb;62(2):281-290.
- Eskandarian S, Grand R, Irani S, Saeedi M, Mirfakhraie R. Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR) Rep Biochem Mol Biol. 2020 Jul;9(2):163-170.
- Zukeran A, Takahashi A, Takaoka S, Mohamed HMA, Suzuki T, Ikematsu S, Yamamoto T. The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells Biochem Biophys Res Commun. 2016 May 27;474(2):233-239.
- Parris TZ, Vizlin-Hodzic D, Salmela S, Funa K. Tumorigenic effects of TLX overexpression in HEK 293T cells Cancer Rep (Hoboken). 2019 Oct;2(5):e1204.
- Maryati M, Airhihen B, Winkler GS. The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module Biochem J. 2015 Jul 1;469(1):169-76.
